Data dredging and false discovery

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The False Discovery Rate in Simultaneous Fisher and Adjusted Permutation Hypothesis Testing on Microarray Data

Background and Objectives: In recent years, new technologies have led to produce a large amount of data and in the field of biology, microarray technology has also dramatically developed. Meanwhile, the Fisher test is used to compare the control group with two or more experimental groups and also to detect the differentially expressed genes. In this study, the false discovery rate was investiga...

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Data Dredging

Suppose there is a given data set and there are a huge number of hypotheses [1] about this data set [2]. If the data is totally random, then say all the hypotheses are actually false. However, owing to the sheer number of hypotheses on a limited data set, it is possible to see some very highly correlated [3] data that are statistically significant [4]. In such cases, data dredging is said to ha...

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Data Dredging

Suppose there is a given data set and there are a huge number of hypotheses [1] about this data set [2]. If the data is totally random, then say all the hypotheses are actually false. However, owing to the sheer number of hypotheses on a limited data set, it is possible to see some very highly correlated [3] data that are statistically significant [4]. In such cases, data dredging is said to ha...

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Data Dredging

Suppose there is a given data set and there are a huge number of hypotheses [1] about this data set [2]. If the data is totally random, then say all the hypotheses are actually false. However, owing to the sheer number of hypotheses on a limited data set, it is possible to see some very highly correlated [3] data that are statistically significant [4]. In such cases, data dredging is said to ha...

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False Discovery Rates

In hypothesis testing, statistical significance is typically based on calculations involving p-values and Type I error rates. A p-value calculated from a single statistical hypothesis test can be used to determine whether there is statistically significant evidence against the null hypothesis. The upper threshold applied to the p-value in making this determination (often 5% in the scientific li...

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ژورنال

عنوان ژورنال: Journal of the American Academy of Dermatology

سال: 2020

ISSN: 0190-9622

DOI: 10.1016/j.jaad.2019.07.061